Scientific Publications and Presentations

Disease-Modifying rdHSV-CA8* Non-Opioid Analgesic Gene Therapy Treats Chronic Osteoarthritis Pain by Activating Kv7 Voltage-Gated Potassium Channels
Frontiers, July 2024

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels
Frontiers, May 2024

Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo
Mammalian Genome, November 2020

Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL
PLoS Genet, June 2019

Human Carbonic Anhydrase-8 AAV8 Gene Therapy Inhibits Nerve Growth Factor Signaling Producing Prolonged Analgesia and Anti-Hyperalgesia in Mice
Gene Therapy, April 2018

Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice
NeuroReport, December 2017

Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes
Methods & Clinical Development, June 2017

Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice
Mammalian Genome, May 2017

Engineered HSV vector achieves safe long-term transgene expression in the central nervous system
Scientific Reports, May 2017

Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes
Methods & Clinical Development, March 2017

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway
PLoS One, March 2015

Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity
PNAS, March 2015