Publications

1. Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo. Upadhyay U, Zhuang GZ, Diatchenko L, Parisien M, Kang Y, Sarantopoulos KD, Martin ER, Smith SB, Maixner W, Levitt RC. Mamm Genome. 2020 Dec;31(9-12):287-294. doi: 10.1007/s00335-020-09848-y. Epub 2020 Nov 28. PMID: 33247772

2. Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL. Upadhyay U, Zhuang GZ, Diatchenko L, Parisien M, Kang Y, Sarantopoulos KD, Martin ER, Smith SB, Maixner W, Levitt RC. PLoS Genet. 2019 Jun 14;15(6):e1008226. doi: 10.1371/journal.pgen.1008226. eCollection 2019 Jun. PMID: 31199789 Free PMC article.

3. Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. Zhuang GZ, Upadhyay U, Tong X, Kang Y, Erasso DM, Fu ES, Sarantopoulos KD, Martin ER, Wiltshire T, Diatchenko L, Smith SB, Maixner W, Levitt RC. Gene Ther. 2018 Jul;25(4):297-311. doi: 10.1038/s41434-018-0018-7. Epub 2018 Apr 24. PMID: 29789638 Free PMC article.

4. Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice. Fu ES, Erasso DM, Zhuang GZ, Upadhyay U, Ozdemir M, Wiltshire T, Sarantopoulos KD, Smith SB, Maixner W, Martin ER, Levitt RC. Neuroreport. 2017 Dec 13;28(18):1215-1220. doi: 10.1097/WNR.0000000000000872.PMID: 28902707 Free PMC article.

5. Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice. Levitt RC, Zhuang GY, Kang Y, Erasso DM, Upadhyay U, Ozdemir M, Fu ES, Sarantopoulos KD, Smith SB, Maixner W, Diatchenko L, Martin ER, Wiltshire T. Mamm Genome. 2017 Oct;28(9-10):407-415. doi: 10.1007/s00335-017-9694-7. Epub 2017 May 25. PMID: 28547032 Free PMC article.

6. Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. Zhuang GZ, Keeler B, Grant J, Bianchi L, Fu ES, Zhang YP, Erasso DM, Cui JG, Wiltshire T, Li Q, Hao S, Sarantopoulos KD, Candiotti K, Wishnek SM, Smith SB, Maixner W, Diatchenko L, Martin ER, Levitt RC. PLoS One. 2015 Mar 3;10(3):e0118273. doi: 10.1371/journal.pone.0118273. eCollection 2015. PMID: 25734498 Free PMC article.

7. Engineered HSV vector achieves safe long-term transgene expression in the central nervous system. Verlengia G, Miyagawa Y, Ingusci S, Cohen JB, Simonato M, Glorioso JC. Sci Rep. 2017 May 4;7(1):1507. doi: 10.1038/s41598-017-01635-1. PMID: 28473703 Free PMC article.

8. Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity. Miyagawa Y, Marino P, Verlengia G, Uchida H, Goins WF, Yokota S, Geller DA, Yoshida O, Mester J, Cohen JB, Glorioso JC. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1632-41. doi: 10.1073/pnas.1423556112. Epub 2015 Mar 16. PMID: 25775541 Free PMC article.

9. Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes. Miyagawa Y, Verlengia G, Reinhart B, Han F, Uchida H, Zucchini S, Goins WF, Simonato M, Cohen JB, Glorioso JC. Mol Ther Methods Clin Dev. 2017 Jun 16;6:79-90. doi: 10.1016/j.omtm.2017.06.001. eCollection 2017 Sep 15. PMID: 28702475 Free PMC article.

10. Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes. Kuroda S, Miyagawa Y, Sato Y, Yamamoto M, Adachi K, Kinoh H, Goins WF, Cohen JB, Glorioso JC, Taniai N, Yoshida H, Okada T. Mol Ther Methods Clin Dev. 2020 Mar 17;17:612-621. doi: 10.1016/j.omtm.2020.03.014. eCollection 2020 Jun 12. PMID: 32300608 Free PMC article